01 / 06Two of these are not testosterone, and that is the first thing to sort out
Search for testosterone treatment and you will be shown three different categories of product wearing broadly the same marketing. Only one of them is testosterone replacement therapy. Separating them is not pedantry; it decides whether you need bloodwork, whether a prescriber is legally involved, and what you are actually swallowing.
/supplements/. It is not testosterone, it is not a prescription, and no bloodwork is required because nothing is being replaced. That may be exactly what someone wants for $35. It is not TRT, and a page that let you leave thinking otherwise would have failed at the first hurdle.
The second category is subtler and it is where the real confusion lives. Enclomiphene is sold by two services on this page as a testosterone protocol. It is not testosterone; it is a selective oestrogen receptor modulator intended to make your own body produce more. Whatever its merits, here is its regulatory position, and we checked it rather than assuming:
The third category is actual testosterone replacement: a controlled, FDA-approved hormone, prescribed against a diagnosis, with bloodwork before and during. That is the category the rest of this page is about, and it is the only one where the monitoring column carries any weight.
02 / 06What the bloodwork is actually for, and why the cadence matters more than the price
The clinical standard here is the Endocrine Society's clinical practice guideline on testosterone therapy in men with hypogonadism, which sets out that treatment follows a diagnosis made on unequivocally low measured testosterone together with symptoms, rather than on symptoms alone. The practical consequence for anyone comparing services is simple: a service that will start you without measuring you first is skipping the step that defines the treatment.
The follow-up bloodwork is not box-ticking either. Testosterone therapy moves several things that are not testosterone, and the panels these services run exist to watch them. Defy Medical's own explainer makes the point plainly, noting that PSA is tracked "to monitor prostate health alongside hormone optimization" and that "most standard labs measure only a handful of markers". Their published position on cadence is honest about its own variability: once a first panel establishes a baseline, follow-up testing "depends on whether you're on a protocol and how your symptoms are trending".
The question that separates these services is not what a month costs. It is who insists on seeing your blood before they start, and how soon they insist on seeing it again. RxGrab, on the comparison below
03 / 06The six, on what they require of you
Read the Labs and Monitoring columns before the price column. Where a service does not publish a figure, the cell says so rather than carrying our guess.
| Service | What you actually receive | Bloodwork it publishes | Monitoring cadence | Published price |
|---|---|---|---|---|
| Maximus | Several protocols: testosterone cream, injectable, oral, and enclomiphene enclomiphene is compounded | Comprehensive lab testing up to 146 markers; an at-home testosterone test covering 10 | States the doctor "tracks your progress through follow-up labs and adjusts your protocol" | protocols from $99.99/mo |
| Defy Medical | Physician-supervised testosterone therapy, presented as a monitored practice rather than a subscription | A comprehensive hormone panel; states most standard labs measure only a handful of markers; tracks PSA | Baseline panel first, then follow-up "depends on whether you're on a protocol and how your symptoms are trending" | not published |
| Henry Meds | Compounded testosterone, or KYZATREX, a genuinely FDA-approved oral capsule approved product | not published on its TRT page | Shipments every 45 days for injectables, 90 days for oral | $129/mo compounded; $179/mo oral KYZATREX |
| Marek Health | Clinician-guided optimisation combining medication, supplementation and nutrition | Labs-first by design: "we start with your lab work and build a personalized strategy" | States it is "not here to write you a script and end the relationship" | not published |
| Nu Image Medical | Enclomiphene rapid-dissolve tablets not testosterone; no approved product exists | not published | not published | from $80/mo |
| Ro | Ashwagandha supplement not a medicine; no prescriber involved | none, and none is needed | none | $35/mo, or $29/mo quarterly |
One service that belongs in this category is not in the table. hone.health returned 114 bytes of markup to us, which is an empty render rather than a page. That is a limitation of our access, not a finding about the company, and we would rather name the gap than quietly publish a shorter list.
04 / 06What FDA-approved testosterone actually looks like
It is worth knowing the shape of the approved category, because it tells you when a service is offering you something outside it. Across approved applications in Drugs@FDA, testosterone exists as an injectable, a gel and a metered gel, a capsule, an extended-release tablet, an extended-release film, an implantable pellet, and a solution. Familiar approved brand names in that set include AndroGel, Jatenzo, Testopel, Striant and the testosterone cypionate and enanthate injectables.
KYZATREX, which Henry Meds sells by name, is a real approved product: application NDA213953, sponsor Marius, an oral capsule, currently marketed on prescription. We checked because a page that names a branded product should be able to show it exists. A compounded cream or an enclomiphene tablet is not in that list, which does not make it unavailable or unlawful, but does mean it has not been through the approval process the approved products went through.
05 / 06Who should not start testosterone online
- Anyone who has not had testosterone measured, twice, in the morning. The diagnosis rests on measurement. A service willing to skip it is selling you a subscription, not a treatment.
- Anyone currently trying to conceive. Exogenous testosterone suppresses the signal that drives sperm production. This is the single most common reason a clinician steers a patient towards a different approach entirely, and it needs a conversation before a purchase.
- Anyone who will not keep up the follow-up bloodwork. The monitoring is not an upsell. It is how haematocrit and PSA changes get caught. If the cadence sounds inconvenient now, it will not become more convenient in month eight.
- Anyone buying a supplement while believing they are buying a hormone. Ro's product at $35 a month is a legitimate thing to want. It is not going to move a measured deficiency, and nobody should discover that a year later.
06 / 06Method, and what we did not do
We read each provider's own published pages on 17 September 2026 and recorded their stated prices, stated bloodwork and stated monitoring. Where a provider does not publish something, the table says not published rather than carrying an estimate, and where a provider would not render for us at all it is named as excluded with the reason.
We did not enrol in any of these services, have bloodwork drawn by them, or obtain any prescription. We make no claim about whether any of these treatments will work for you, and nothing here is medical advice or a recommendation to take anything. What this page compares is access, requirements, monitoring and price.
The regulatory facts are all reproducible. The approval records come from Drugs@FDA and the FDA National Drug Code directory, and every count quoted above, including the zero for enclomiphene, was run alongside a positive control to confirm the query could return a result at all. If any figure on this page is wrong, those databases are where it will show.
Lab panels and testosterone are both cash-priced items, so state prescription assistance programmes can move the total, and Health Britannica covers the endocrinology this page deliberately does not.
- U.S. Food and Drug Administration. Drugs@FDA: FDA-Approved Drugs. Approved dosage forms and brands for testosterone; KYZATREX, NDA213953; zero approved applications for enclomiphene against five for clomiphene as a control.
- U.S. Food and Drug Administration. National Drug Code Directory. The 25 enclomiphene listings, all registered as bulk ingredient powder.
- Bhasin S, et al. "Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline." Journal of Clinical Endocrinology & Metabolism, 2018. The standard that defines treatment as following a diagnosis rather than symptoms alone.
- Defy Medical. What's in a Comprehensive Hormone Panel? Published explanation of baseline and follow-up testing, and of PSA monitoring.
- Ro. Testosterone Support Supplement. Product classification, ingredient and pricing, read 17 September 2026.
- Provider pricing and protocol pages. Linked inline in the comparison table above, each read on 17 September 2026.
Is enclomiphene FDA-approved?
No. Drugs@FDA returns zero approved applications for enclomiphene as an active ingredient, while the same search returns five for clomiphene, so the query does find approved products when they exist. Enclomiphene appears in the FDA's NDC directory only as bulk ingredient powder, which means anything dispensed to a patient is compounded.
Does a testosterone supplement raise testosterone?
A supplement is not a hormone and is not regulated as a medicine. Ro's product is ashwagandha, sold at $35 a month under its own supplements section. If you have a measured deficiency, that is a different problem with a different category of answer.
How often should bloodwork be repeated on TRT?
That is a clinical decision for your prescriber, and the services here describe it differently: Defy Medical ties follow-up to whether you are on a protocol and how symptoms are trending, while Maximus describes adjusting the protocol on follow-up labs. What matters when choosing is that a service has a published position at all.
Which is cheapest?
On published price, Ro at $29 to $35 a month, but that is a supplement rather than therapy. Among actual testosterone protocols, Maximus publishes from $99.99 a month and Henry Meds $129 for compounded or $179 for the approved oral capsule. Two services publish no price at all.