Four axes from current statute and agency guidance. Teal bar = substitution/assistance/access in place; amber = permissive or absent.
| Generic substitution mandate | Permissive |
| State Pharmaceutical Assistance Program | No broad SPAP |
| 90-day fills permitted | Allowed |
| PMP mandatory prescriber query | Required by statute |
Mississippi permits but does not mandate generic substitution. Under Miss. Code Ann. § 73-21-117, a pharmacist may substitute a less expensive equivalent drug product unless the prescriber has indicated "dispense as written" or otherwise prohibited substitution. The substitute must be FDA AB-rated. Patient consent is required.
Mississippi Division of Medicaid maintains the Mississippi Medicaid Preferred Drug List. Mississippi Medicaid runs primarily as fee-for-service (Mississippi did not expand Medicaid). Non-preferred drugs require prior authorization initiated by the prescriber.
Preferred Drug List: View current PDL
Prior authorization contact: MS Medicaid Pharmacy: 1-800-884-3222
Mississippi does not operate a Medicare-recognized SPAP. Low-income Mississippians use Medicare Part D Extra Help (LIS), Mississippi Division of Medicaid (if eligible), manufacturer Patient Assistance Programs, and Mississippi Insurance Department, SHIP for Medicare enrollment counseling.
Eligibility: No state SPAP. Mississippi Insurance Department, SHIP helps with Medicare enrollment.
Mississippi permits 90-day fills of non-controlled chronic medications at retail and mail-order pharmacies. Out-of-state pharmacies must hold a Mississippi Nonresident Pharmacy license from the Board of Pharmacy. Federal CSA refill limits apply to controlled substances.
Mississippi operates the Mississippi Prescription Monitoring Program, under Miss. Code Ann. § 73-21-127. Prescribers must check the PMP before issuing certain controlled-substance prescriptions. Dispensers must report Schedule II-V dispensing within one business day.
PMP portal: Mississippi Prescription Monitoring Program
Mississippi hosts a substantial 340B network including University of Mississippi Medical Center, Baptist Health Systems, FQHCs across Jackson/Gulf Coast/Delta counties, and Ryan White clinics.
Find a 340B clinic in Mississippi: HRSA OPAIS database (MS filter)
Our sister site OmniRx maintains a federal-side patient assistance program directory covering manufacturer PAPs, foundation copay assistance, GoodRx-style discount cards, and 340B locators applicable nationwide.
Once the law side is clear, the next question is which pharmacy actually has the cheapest fill. Use the RxGrab Pharmacy Finder to compare CostPlus Drugs, Costco, Walmart, Amazon Pharmacy, and other discount pharmacies on your specific medication, and read our generic vs brand explainer for the bioequivalence rules behind every substitution.
Yes unless your prescriber wrote "dispense as written." Under Miss. Code Ann. § 73-21-117 substitution is permissive.
No. Use federal Extra Help, Mississippi Medicaid if eligible, manufacturer Patient Assistance Programs.
Mississippi did not expand Medicaid, so eligibility is narrower. Pharmacy benefits run as fee-for-service with a single state PDL.
Yes for certain controlled-substance prescriptions under Miss. Code Ann. § 73-21-127.