SYNTHROID: what pharmacies pay, and what that tells you
SYNTHROID costs a pharmacy a median of $1.66 per unit. Its generic equivalent costs $0.0609, which makes the brand 27.3 times the price of the same molecule. That is what the pharmacy pays to acquire it. It is not your price: a dispensing fee and margin sit between this number and your receipt.
A smaller gap, and still the lever worth pulling
SYNTHROID runs 27.3 times its generic equivalent. That is modest next to the extremes in this corpus and it is still the largest single change available on this drug, because its price is otherwise stable across pharmacies.
Where it sits against every other priced drug
Acquisition cost percentile, 3,439 priced products
This sits in the middle of the corpus, the range where where-you-fill-it genuinely changes the total.
The brand and the generic, side by side
Acquisition cost per unit, CMS's own correspondence
$1.66 against $0.0609. The generic bar is drawn to scale, which is why it is barely visible at 27.3x. CMS publishes this correspondence per product, so it is a comparison of the same thing rather than a match on names.
What the spread tells you about shopping around
Between the cheapest tenth of listings and the dearest tenth, SYNTHROID varies by almost nothing. That is a tight band. That is less ordinary at this cost level, where products more often vary between suppliers. Pharmacies are buying it at close to the same price, so a difference in what you are charged is a difference in fees and margin rather than in the drug.
The drug is cheap. The route is what costs you.
SYNTHROID costs a pharmacy $0.0609 a unit. Almost none of what you pay is that number. A dispensing fee and a margin sit on top, and both are set by where you fill it and under what programme. These are the routes worth checking, and what each one is actually for.
- Cost Plus Drugs sells at a stated markup over its own acquisition cost, so the pharmacy margin is visible rather than inferred. What we found
- Honeybee Health a mail-order pharmacy that posts cash prices publicly, which makes it a useful sanity check on any card quote. What we found
- Amazon Pharmacy mail order, so it competes on the dispensing fee rather than on the drug. What we found
- GoodRx a discount card negotiated per pharmacy, so the same drug can differ between two shops on one street. What we found
- SingleCare the same mechanism as a rival card, and worth checking against it rather than instead of it. What we found
- RxSaver another card on the same model; cards are cheap to compare and routinely disagree with each other. What we found
- WellRx a fourth card, listed because checking one card and stopping is the most common way to overpay. What we found
- Blink Health prepay-then-collect, which prices the drug before you reach the counter. What we found
- Costco membership pharmacy pricing, which US federal law makes available without a membership. What we found
- Walmart a flat-price generic list, which beats a card on some drugs and loses badly on others. What we found
- CVS and Walgreens, the default retail route, and usually the one every other option is measured against. What we found
We do not quote a per-pharmacy price for SYNTHROID, because that varies by pharmacy, by ZIP code and by week, and we have not measured it for this drug. What is measured here is the acquisition cost above, from CMS NADAC. The order of these routes is editorial and fixed; it is not for sale, and no placement here implies a medical recommendation.
What this page is, and is not
Every figure here is CMS NADAC, the federal survey of what retail pharmacies pay to acquire a drug. It is public-domain federal data and it is the cleanest available floor. It excludes your dispensing fee, your pharmacy's margin, your insurance design and any discount-card pricing, all of which sit between this number and what you hand over. Nothing here is medical advice.
Source: CMS NADAC (National Average Drug Acquisition Cost), Centers for Medicare & Medicaid Services, dataset generated 2026-07-22. See how SYNTHROID compares across 385 brand and generic pairs, or look up another drug in our price tools.