SYNTHROID costs a pharmacy a median of $1.66 per unit. Its generic equivalent costs $0.0609, which makes the brand 27.3 times the price of the same molecule. That is what the pharmacy pays to acquire it. It is not your price: a dispensing fee and margin sit between this number and your receipt.
This sits in the range where the difference between pharmacies is real money over a year, and the spread below tells you how much of a difference to expect.
Acquisition cost percentile, 3,439 priced products
This sits in the middle of the corpus, the range where where-you-fill-it genuinely changes the total.
Acquisition cost per unit, CMS's own correspondence
$1.66 against $0.0609. The generic bar is drawn to scale, which is why it is barely visible at 27.3x. CMS publishes this correspondence per product, so it is a comparison of the same thing rather than a match on names.
Between the cheapest tenth of listings and the dearest tenth, SYNTHROID varies by almost nothing. That is a tight band. Pharmacies are buying it at close to the same price, so a difference in what you are charged is a difference in fees and margin rather than in the drug.
Every figure here is CMS NADAC, the federal survey of what retail pharmacies pay to acquire a drug. It is public-domain federal data and it is the cleanest available floor. It excludes your dispensing fee, your pharmacy's margin, your insurance design and any discount-card pricing, all of which sit between this number and what you hand over. Nothing here is medical advice.
Source: CMS NADAC (National Average Drug Acquisition Cost), Centers for Medicare & Medicaid Services, dataset generated 2026-07-22. See how SYNTHROID compares across 385 brand and generic pairs, or look up another drug in our price tools.